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. 1998 Apr 1;18(7):2550–2559. doi: 10.1523/JNEUROSCI.18-07-02550.1998

Fig. 6.

Fig. 6.

Estradiol effects on miniature EPSCs in cultured neurons. A, Spontaneous mEPSCs recorded from control and estradiol-treated neurons (24 hr) with a patch pipette containing CsCl. The recording medium contained TTX and 50 μm bicuculline. Cells were held at −80 mV. B, Averaged mEPSC of ∼20–30 such events in both control and estradiol-treated cells. The magnitude of synaptic current is about the same in the two cells, but its decay time constant is slightly slower in the estradiol-treated cell. C, D, Frequency distribution histograms of mEPSCs recorded in five control and six estradiol-treated cells, respectively. A sample of 20 sec was recorded from each cell. The histograms summarize a subset of 266 events recorded in the control and 506 events recorded in the treated group for an equal duration of time. The mean size of these events was −64.1 ± 2.69 pA in the control and −76.4 ± 2.95 pA in the estradiol-treated cells.E, Cumulative histograms of the events recorded in the control and estradiol-treated cells show an overall similar distribution of mEPSP sizes.