Fig. 3.

Mean percent change in overall DNMS performance is shown for the CX516 (circles) and Control (squares) group over the entire 32 d treatment period. Mean DNMS performance over all trials was calculated for each individual session and transformed to percent increase from baseline performance. Mean baseline performance was 72% over days 1–8. The maximum level corresponded to a mean of 88% correct (days 26–32). Each point is the mean performance over all animals within each group for that day. The error bar indicates the largest SEM across all days. Pre, CX516, andPost indicate drug administration (35 mg/kg) to CX516 on alternate days (open circles). On all other days (closed circles), animals received vehicle only. Control group (filled squares) received vehicle on all 32 d. Asterisks indicate significant increases from Control group on that day (*p < 0.01; **p < 0.001).