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. 1998 May 15;18(10):3897–3908. doi: 10.1523/JNEUROSCI.18-10-03897.1998

Fig. 4.

Fig. 4.

Fos-positive cell counts in PC. All NDB injections were made into the left hemisphere. Animals receiving unilateral injections of vehicle, saline in NDB (left hemisphere) had large increases in Fos-positive cells bilaterally in PC 45 min after an intramuscular injection of soman (columns 1, 2). Animals receiving a unilateral injection of 192-IgG-saporin in the NDB (left hemisphere) had few Fos-positive cells 45 min after an intramuscular injection of vehicle, saline (columns 3, 4). Unilateral injections of192-IgG-saporin in NDB (left hemisphere) inhibited the large increases in Fos-positive cells in PC 45 min after soman administration (column 5). Note that the number of Fos-positive cells in PC ipsilateral to the lesioned NDB 45 min after soman (column 5) was not significantly different from animals receiving 192-IgG-saporin and no soman (columns 3, 4). Also, the number of Fos-positive cells in PC ipsilateral to the unlesioned NDB (column 6) was significantly fewer than in control animals 45 min after soman administration (columns 1, 2). By 90 min after soman the number of Fos-positive cells in PC ipsilateral to the lesioned NDB (column 7) was significantly fewer than the number of Fos-positive cells 45 min after soman administration in animals receiving vehicle, saline (columns 1, 2). The number of Fos-positive cells in PC ipsilateral to the unlesioned NDB (column 8) was similar to the number in control animals 45 min after soman administration (columns 1, 2).