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. 1998 May 15;18(10):3639–3649. doi: 10.1523/JNEUROSCI.18-10-03639.1998

Fig. 3.

Fig. 3.

Impaired performance of RIIβ knock-out mice on the rotarod task. A, RIIβ−/−(open squares; n = 11) and wild-type control mice (closed squares; n = 13) were tested for their ability to stay on the accelerating rotarod. Ten trials were conducted on the first day and four on the second day (error bars represent SEM). ANOVA for repeated measures revealed a significant effect of trials 1–10 on day 1 in both wild-type (F(9,108) = 7.62; p < 0.001) and RIIβ knock-out mice (F(9,90) = 5.11; p < 0.001) as well as a significant effect of genotype (F(1,22) = 14.07,p < 0.002 on day 1;F(1,22) = 10.24, p < 0.005 on day 2). B, When tested at a lower rate of acceleration, RIIβ−/− (open squares;n = 18) mice were impaired significantly, as compared with wild-type control mice (closed squares;n = 17; F(1,33) = 60.76,p < 0.001 on day 1;F(1,33) = 26.90, p < 0.001 on day 2).