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Stimulated release of CRH from mediobasal hypothalami (MBH) in vitro of transgenic mice (TG) and wild-type mice (WT). After preincubation for 45 min, depolarization-induced CRH release was evoked by incubation of the MBHs in the presence of KRB containing 56 mmK+ for 30 min. Data are expressed as mean and SEM (n = 10–11); *p < 0.05 versus WT.
