Fig. 7.

Effect of interleukin-1β on POMC mRNA levels (top panel) and POMC heteronuclear RNA (POMC hnRNA) levels (bottom panel) in anterior pituitary glands of wild-type mice (black bars) and GR antisense transgenic mice (hatched bars). Groups of mice were injected intraperitoneally with hrIL-1β (1 μg/mouse; IL-1β) or vehicle (SAL) or were left untreated (UNT) and then were decapitated 4 hr later. POMC mRNA and POMC hnRNA levels are given as transmittance, and data are expressed as mean and SEM (n = 5 and n = 9–10 forPOMC mRNA and POMC hnRNA, respectively); #p < 0.05 versus UNT (one-way ANOVA on pooled data of wild-type and transgenic mice).