Fig. 3.
Effect of Src on OBN outward current.A, Outward currents were elicited by depolarizing from −90 to +40 mV at 1 min intervals. Whole-cell patch electrodes were back-filled with either control patch solution (Control) or 0.5 U of recombinant c-Src (c-Srcpp60). Every second pulse during a 24 min recording period is shown for each cell.B, Change in peak outward current as a function of time in a control (•) and an Src-treated (○) cell. Normalization as in Figure 2. C, Mean normalized peak current amplitudes after 24 min of recording for cells treated with control patch solution (Control) or active c-Src (c-Srcpp60). *Significantly different, Student’s t test. Shown also for comparison is the normalized peak current remaining after the same time period in cells treated with heat-inactivated c-Src (Heat-inactivated).