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Sensitivity of P2X4+6 receptors to the agonists ATP and 2MeSATP. A, Similar ATP dose–response profile between heteromeric P2X4+6 channels and homomeric P2X4 receptors in Xenopus oocytes.B, Heteromeric P2X4+6 receptors showed increased sensitivity to 2MeSATP compared with P2X4receptors. Values are normalized to the response to 300 μm ATP (averages ± SEM from 3 to 7 oocytes per point in 2 independent experiments).
