Fig. 1.

Tau antibodies used in this study. Schematic diagram of the longest tau isoform, showing the epitope locations of the antibodies used in this study. The antibodies used are indicated inbold, and the amino acid position of the epitopes is indicated in parentheses. The MT binding repeats arestippled. Antibodies 304, T49, and MN 7.51 recognize the primary tau sequence independently of phosphorylation status (indicated as Pi). 12E8, PHF-1, and AT8 recognize phosphorylated epitopes (P+), whereas Tau-1 binds to a dephosphorylated epitope (P−).