Table 2.

Effects of sense, mismatch, and antisense mGluR₁ oligonucleotide infusions on different sensory responses of dorsal horn neurons

Stimulus	Stimulus-evoked response (Hz)
	Normal control	Sense reagent-treated	Mismatch reagent-treated	Antisense reagent-treated
	(n = 8)	(n = 7)	(n = 6)	(n = 6)
Innocuous brush	17.2  ± 2.3	22.1  ± 5.7	14.5  ± 2.4	20.4  ± 5.6
Acute chemical nociception	30.7  ± 7.2	22.7  ± 7.7	20.9  ± 3.9	1.4  ± 0.5*
Sustained activity caused by repeated nociceptive stimuli	10.1  ± 2.6	7.4  ± 1.8	7.3  ± 1.6	0.5  ± 1.8*

The sensory responses monitored were the acute neuronal responses to innocuous brush (mean taken over 10 sec) and the chemical algogen mustard oil applied to the peripheral receptive field (mean taken over 10 sec, 20–40 sec after initial application), as well as the sustained sensitized activity caused by repeated application of mustard oil (mean taken over 10 sec, 15–18 min after the first three applications). Basal firing rates of neurons were all within the range 0–1.0 Hz and were no different between treatments. Values are means ± SEM with numbers of neurons in parentheses. *Indicates significantly different from normal, sense, or mismatch reagent controls; p < 0.05, Mann–Whitney U test.