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. 1998 Dec 15;18(24):10231–10240. doi: 10.1523/JNEUROSCI.18-24-10231.1998

Fig. 1.

Fig. 1.

Bursts of synaptic activity in whole-cell recordings of E18 hippocampal neurons cultured after 2 weeks. The inward current deflections are produced by postsynaptic currents.A, Shown is an example of recordings. B, Shown is the time course of the BDNF effect. The effect of BDNF (100 ng/ml) on the burst frequency appeared ∼30 sec after application. The increased frequency and the increased magnitude of the integrated current per minute (denoted synaptic charge) recovered to baseline ∼5 min after washout of BDNF. C, D, Average values of bursting frequency and of synaptic charge in and after BDNF application.