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. 1998 Dec 15;18(24):10700–10708. doi: 10.1523/JNEUROSCI.18-24-10700.1998

Fig. 2.

Fig. 2.

Effect of precipitated opiate withdrawal on BDNF mRNA expression in LC. A, Film autoradiograms demonstrating BDNF cRNA hybridization in LC of control rats and rats exposed to 2 or 6 hr of opiate withdrawal. B, Film autoradiograms of BDNF mRNA expression in LC in control rats and rats exposed to 20 or 70 hr of opiate withdrawal. C, Densitometric analysis of film autoradiograms reveals robust increases in BDNF mRNA levels at 2, 6, 20, and 70 hr of opiate withdrawal as compared with control (p < 0.05). Results are expressed as a percentage of control values. Values are the mean ± SEM (SEM for 2 and 6 hr control group = ±6; SEM for 20 and 70 hr control group = ±6.5.) *,†Significantly increased from control. ** Significantly increased from control and 2 hr. ††Significantly different from control and 20 hr. Scale bar, 500 μm.