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. 1998 Jan 1;18(1):237–250. doi: 10.1523/JNEUROSCI.18-01-00237.1998

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Copyright © 1998 Society for Neuroscience

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Fig. 3. — Expression of Sox10 in cultured cells.A, Total cellular RNA from Schwann cells (SC) and several cell lines was analyzed for the expression of Sox10 mRNA by Northern blot. Cell lines included NB4 1A3 mouse neuroblastoma, N1E-115 mouse neuroblastoma, 3T3 mouse fibroblasts, Rat1 fibroblasts, Neuro2A mouse neuroblastoma, C6 rat glioma, B103 rat tumor cells, 33B rat oligodendroglioma, HJC hamster glioma, P19 mouse embryonal carcinoma, and U138 human glioblastoma. Filters were hybridized consecutively with probes specific for Sox10 (top panel) and GAPDH (bottom panel). B, Total cellular RNA from mature oligodendrocytes (OL) and CG-4 cells was analyzed for the expression of Sox10 mRNA by Northern blot. CG-4 cells were either maintained in the undifferentiated state (−) or differentiated for various time intervals (1d–5d). Filters were hybridized consecutively with probes specific for Sox10 (top panel), MBP (middle panel), and GAPDH (bottom). C, Whole-cell extracts from purified rat Schwann cells (SC), primary oligodendrocyte progenitors (O2-A) and mature oligodendrocytes (OL) were analyzed for the presence of Sox10 protein by Western blot using a rabbit antiserum raised against Sox10 holoprotein.