Fig. 1.

A, Photomicrographs showing similarity in cerebral vasculature in wild-type (Wt) and knock-out mutant mice (Sod2 −/+), respectively. The origins of the MCA and the other major blood vessels involved in the Willis’ circle were almost the same in both animals. The distribution of the MCA territory was also similar between the two animals.B, Residual rCBF of the MCA territory cortex measured by laser Doppler flowmetry during MCA occlusion. The ischemia was induced at the same level in both wild-type and knock-out mutant mice.