Table 1.

Talairach coordinates for masked fearful vs masked happy faces

No.	Location in brain	pvalue	Talairach coordinates
			x	y	z
1.	Amygdala	3.7  × 10−5	18	−6	−15
2a.	Amygdala/	1.6  × 10−4	−15	0	−12
2b.	Substantia innominata	2.9  × 10−4	−12	0	−9
3.	Inferior prefrontal cortex	1.6  × 10−4	−28	42	9

Areas of significantly increased BOLD fMRI signal intensity across whole brain during presentation of masked fearful faces versus masked happy faces. Similar to Figures 1, 2, 3, data presented are for the eight subjects who reported not having seen fearful or happy faces. Reported probability values and Talairach coordinates reflect the maximum activated voxel. Activation 1 corresponds to the activation pictured in Figure 2. Activation 2a, b corresponds to the activation pictured in Figure 3. The location of maximum voxels within the temporal lobe (amygdala) and basal forebrain (substantia innominata) are reported in 2a and 2b, respectively. The Talairach atlas (Talairach and Tournoux, 1988) suggests that the location of Activation 2a should be described as temporal cortex. Our designation of this locus as within the amygdala is based on (1) inspection of high resolution structural data, (2) other human structural atlases (DeArmond et al., 1993) depicting the amygdala as prominent at the anterior to posterior location of the anterior commissure (y = 0), and (3) the similar response topography to the amygdala activation in Figure 2(increase to fear, decrease to happy). Because activation of inferior frontal cortex was not predicted and our Bonferroni corrected significance threshold is based on the smaller size of the amygdala, we note that activation of this region did not achieve the appropriate Bonferroni corrected threshold for whole brain (see Results).