Table 3.
Monoaminergic neuronal markers in control and methamphetamine-treated baboons
| Putamen | ||||||
|---|---|---|---|---|---|---|
| DA | DOPAC | [3H]WIN | [3H]DTBZ | 5-HT | 5-HIAA | |
| Control (n = 3) | 8.13 ± 0.79 | 0.85 ± 0.11 | 2451 ± 362 | 3700 ± 575 | 0.32 ± 0.05 | 0.60 ± 0.07 |
| Methamphetamine | ||||||
| 0.5 mg/kg | 5.43 (−33) | 0.68 (−20) | 1224 (−50) | 2705 (−27) | 0.23 (−28) | 0.49 (−18) |
| 4.67 (−42) | 0.47 (−45) | 1471 (−40) | 2704 (−27) | 0.30 (−06) | 0.53 (−12) | |
| 1.0 mg/kg | 4.10 (−50) | 0.40 (−53) | 986 (−60) | 2040 (−45) | 0.24 (−25) | 0.42 (−30) |
| 4.43 (−45) | 0.47 (−45) | 799 (−67) | 1957 (−47) | 0.18 (−44) | 0.53 (−12) | |
| 2.0 mg/kg | 4.60 (−43) | 0.28 (−67) | 483 (−80) | 1126 (−70) | 0.04 (−88) | 0.22 (−63) |
| 1.79 (−78) | 0.56 (−34) | 651 (−73) | 1516 (−59) | 0.10 (−69) | 0.24 (−60) | |
| 3.74 (−54) | 0.31 (−64) | 1082 (−56) | 2797 (−24) | 0.21 (−34) | 0.35 (−42) | |
Methamphetamine was given intramuscularly at a dose of 0.5, 1, and 2 mg/kg. Each dose was given four times, at 2 hr intervals. Animals were killed for neurochemical studies 2–3 weeks after methamphetamine treatment. Control values represent the mean ± SEM (n = 3) and are provided in the following units: dopamine (DA), dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in μg/gm tissue; [3H]WIN-35,428 and [3H]dihydrotetrabenazine (DTBZ) in dpm/mg tissue. Values for each methamphetamine-treated baboon are provided, with the percentage change shown in parentheses.