Table 4.
Regional cortical 5-HT and NE concentrations in control and methamphetamine-treated baboons
| Frontal cortex | Parietal cortex | Temporal cortex | ||||
|---|---|---|---|---|---|---|
| 5-HT | NE | 5-HT | NE | 5-HT | NE | |
| Control (n = 3) | 101.1 ± 16.8 | 36.7 ± 2.8 | 95.1 ± 4.6 | 39.1 ± 5.7 | 175.0 ± 5.5 | 29.4 ± 3.5 |
| Methamphetamine (n = 3) | 52.3 ± 2.04-a | 31.2 ± 2.5 | 57.0 ± 2.34-a | 42.6 ± 6.1 | 119.6 ± 5.14-a | 22.3 ± 3.1 |
Methamphetamine was given intramuscularly at a dose of 2 mg/kg. Each dose was given four times, at 2 hr intervals. Animals were killed for neurochemical studies 2–3 weeks after methamphetamine treatment. Control values represent the mean ± SEM (n = 3). Values are in μg/mg tissue.
F4-a
Designates significant difference from control (p < 0.05).