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Progesterone withdrawal converts a benzodiazepine antagonist into an agonist. Graph depicts significant enhancement of GABAA-gated current by the benzodiazepine antagonist RO15-1788 after progesterone withdrawal in pseudopregnant animals (PP PWD). In contrast, under control and pseudopregnant (PP) conditions, RO15-1788 did not significantly alter GABAA-gated current. n = 10–12 cells per group.
