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Percent increase in GABA-gated current by 3α,5α-THP (10 nM)
| Control | 81 ± 17.3* |
| Pseudopregnant, 1 d wd | 11.2 ± 5.2 |
Progesterone withdrawal abolishes the modulatory effect of 3α,5α-THP on GABA current. After progesterone withdrawal (Pseudopregnant 1 d wd), 10 nM 3α,5α-THP was ineffective in significantly altering GABA current. In contrast, under control conditions, this neurosteroid enhanced GABA current up to 80%.n = 20 cells per group.
*p < 0.05 versus 1 d wd.
