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Dominant-negative BMP-4 receptor alters the development of cortical precursors in situ.A, B, Cells infected with DAP and grown in culture for 3 d. Cells have migrated away from the VZ surface and have extended processes. C–E, Cells infected with DEL and grown in culture for 3 d. In contrast to cells infected with DAP, most cells infected with the DEL virus are confined to the VZ and do not extend apical processes. Scale bar: A–C, 20 μm; D, E, 10 μm.
