Fig. 1.

Comparison of the amino acid sequences of Kir7.1 with representative subunits of other Kir subfamilies. The predicted 360 amino acids of human Kir7.1 (single-letter code) are shown aligned with sequences of human Kir1.2 (GenBank accession numberU73192), human Kir2.1 (U12507), human Kir3.3 (U52152), rat Kir5.1 (X83581), and human Kir6.2 (D50582). Residues are shaded inblack in instances in which other subunits are identical to Kir 7.1; asterisks denote residues conserved in all known Kir channels, and boxed residues (arrowheads) indicate where Kir7.1 is different from the consensus of all other Kir channels. Outlined also are the transmembrane segments M1 and M2 and the pore-forming P-region (H5). Amino acid gaps within the alignment are indicated by short bars. The GenBank accession number for the human and rat Kir7.1 sequences are AJ006128and AJ006129, respectively.