Fig. 6.

The localization of degeneration of ENFs after an intradermal injection of 20 μg of capsaicin as shown by confocal images of skin biopsy from one subject. Top, Montage of confocal images that span across the skin biopsy. Abundant ENFs are seen only at the far right portion of the biopsy, which was located outside the capsaicin injection site and presumably not exposed to the neurotoxin. Bottom, The two opposite ends of the skin biopsy, outlined by thesquares in the top image, shown at greater magnification to illustrate differences in epidermal innervation.