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. 1998 Nov 1;18(21):8700–8711. doi: 10.1523/JNEUROSCI.18-21-08700.1998

Fig. 1.

Fig. 1.

Lf-NT amino acid sequence.A, Prepro-amino acid sequence of Lf-NT. The mature protein sequence is compared with NGF, NT-3, BDNF, and NT-4/5 from rat as well as platy fish NT-6. Regions that are variable between neurotrophins (variable regions I–V) areboxed and marked by roman numerals. The two insertions in variable regions II andIII are indicated (in 1, in 2).B, The complete coding region is located in one 3′-exon and includes signal sequence, a pro-region, and the mature neurotrophin indicated by the shaded box. The putative proteolytic cleavage site is marked by an arrow. C, Three-dimensional structure model of the peptide backbone of a NGF protomer with the variable regions indicated by a shaded backbone and roman numerals.D, A model of Lf-NT where the two insertions in Lf-NT are introduced into the NGF backbone to illustrate their positions. N-term, Amino terminus;C-term, C terminus.