Fig. 1.
FEN-induced corticosterone release determined 1 week after cessation of the 4 d saline (1 ml/kg, s.c., b.i.d.) or FEN (20 mg/kg, s.c., b.i.d.) dosing regimen. Rats from each pretreatment group were challenged with intravenous saline or FEN (1.5 or 3.0 mg/kg). Serial blood samples were withdrawn immediately before (time 0) and at 15, 30, and 60 min after intravenous injection. Corticosterone values are mean ± SEM for n = 8 rats per group. *p < 0.05 with respect to corresponding saline pretreatment group at the specified time point.
