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RyR control of rod transmitter release depends on presynaptic voltage. A, In dual recordings of a rod and an OFF bipolar cell, the rod was clamped at −80 mV and then stepped to −50, −40, or −20 mV for 100 ms. This produced postsynaptic currents in an OFF bipolar cell clamped at −70 mV (red, blue, and black traces, respectively). B, After treatment with 100 μm ryanodine, the same stimulation protocol was repeated.
