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. 2006 Feb 8;26(6):1721–1729. doi: 10.1523/JNEUROSCI.3990-05.2006

Figure 2.

Figure 2.

LTD is impaired in the Schaffer collateral→CA1 pathway of hippocampal slices from mature (P26–P35), but not in immature (P14–P18), double Ras-GRF knock-out mice. LFS (900 pulses at 1 Hz) was used to induce LTD in mature (A) and immature (B) hippocampal brain slices from wild-type (WT) and double Ras-GRF knock-out mice [grf1/grf2(−/−)]. The recorded fEPSP slope is expressed as a percentage of baseline ± SEM; data were pooled from each group [closed boxes, WT slices (n = 8 in A, B); open circles, grf1/grf2(−/−) slices (n = 9 in A, B)]. C, Hippocampal brain slices were pretreated with buffer containing the p38 inhibitor SB203580 (10 μm; filled triangle; n = 6), the MEK inhibitor U0126 (20 μm; open circle; n = 7), or the NMDAR inhibitor d-AP-5 (100 μm; filled square; n = 7).