Figure 2.
Nicotine self-administration in P and NP rats. a, b, Mean ± SEM number of nicotine infusions and active lever responses during the first 24 d of nicotine self-administration (0.03 mg/kg per infusion) under FR-1, FR-2, and FR-5 reinforcement schedules. c, d, Mean ± SEM number of nicotine infusions and nicotine intake (milligrams per kilogram); data are from the dose–response determination during days 25–33 of nicotine self-administration training (3 d per dose). *Different from the NP group; p < 0.05 (Newman–Keuls post hoc test); n = 9–12 per line.