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. 2006 Mar 1;26(9):2522–2530. doi: 10.1523/JNEUROSCI.4083-05.2006

Figure 2.

Figure 2.

RGS9-2 and α-actinin-2 are coexpressed and interact in striatum. A, RGS9-2 and α-actinin-2 exhibit a similar distribution in the rat forebrain, with robust expression in striatum. B, Coimmunoprecipitation of RGS9-2, α-actinin-2, and NMDA receptor subunit NR1 from striatum. Antibodies detect robust expression of these proteins plus DARPP-32 in striatal supernatant (Sup). Immunoprecipitation of endogenous RGS9-2 from striatal extract results in coimmunoprecipitation of α-actinin-2 and NR1, but not DARPP-32 (column 1). Conversely, immunoprecipitation of DARPP-32 failed to coimmunoprecipitate either RGS9-2, α-actinin-2, or NR1 (column 2). This experiment was replicated three times with comparable results.