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. 2006 Mar 1;26(9):2522–2530. doi: 10.1523/JNEUROSCI.4083-05.2006

Figure 3.

Figure 3.

Effect of RGS9-2 on NMDAR CDI in HEK-293 cells. A1, CDI in a HEK-293 cell transfected with the NR1 and NR2A subunits and pcDNA3. A2, In a different cell, transfection with α-actinin-2 does not affect CDI. A3, Transfection of RGS9-2, however, results in an inhibition of CDI. A4, An even stronger suppression of CDI is seen after cotransfection of RGS9-2 and α-actinin-2. B, Summary plot comparing the magnitude of CDI, expressed as percent inhibition of the peak NMDA current under control conditions. n = 36–44 cells per group; *p < 0.01 against pcDNA3; **p < 0.01 against α-actinin-2 alone. C, Expression of Gβ5 does not modify the ability of RGS9-2 to regulate CDI (n = 16–18 cells per group). Error bars indicate SE.