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CD’s inhibitory effect on myelination is reversible. Cultures were grown in myelination-permissive medium with 0.75 μg/ml CD for 1 week and then without CD for an additional week to determine whether drug toxicity prevented SC function. At removal of CD, SCs spiraled membranes around axons. An SC (S), shown with its nucleus (N), elaborated 20 myelin lamellae (small asterisk) around an axon (large asterisks), and an adjacent SC (S) is beginning to myelinate. Magnification, 25,000×.
