Table 1.
Neuronal distribution of PDGF-αR immunoreactivity in developing and adult mouse CNS
| Location | Age | |||
|---|---|---|---|---|
| P1 | P7 | P15 | P120 | |
| Olfactory system | ||||
| Periglomerular layer | +++ | +++ | +++ | +++ |
| Internal granular layer | +++ | +++ | ++ | + |
| Mitral cell layer | + | ++ | +++ | +++ |
| Olfactory ventricle | +++ | +++ | ++ | ++ |
| Anterior olfactory nucleus | +++ | +++ | +++ | +++ |
| Olfactory tubercle | +++ | +++ | +++ | +++ |
| Cerebral cortex | +++ | +++ | ++ | ++ |
| Striatum | − | − | − | − |
| Globus pallidus | nd | +++ | ++ | ++ |
| Hippocampus | ||||
| CA1–CA4 | +++ | +++ | ++ | ++ |
| Dentate gyrus | +++ | +++ | ++ | ++ |
| Subiculum | nd | nd | ++ | ++ |
| Thalamus | +++ | +++ | ++ | ++ |
| Substantia nigra | ||||
| Reticular | nd | nd | ++ | ++ |
| Compact | nd | nd | ++ | ++ |
| Colliculus | nd | nd | ++ | ++ |
| Cerebellum | ||||
| Molecular layer | − | − | − | − |
| Purkinje cell layer | ++ | ++ | ++ | +++ |
| Granule cell layer | +++ | +++ | + | − |
| Cerebellar nucleus | nd | nd | ++ | +++ |
| Pons–medulla | ||||
| Facial nucleus | nd | nd | ++ | ++ |
| Vestibular nucleus | nd | nd | ++ | ++ |
| Trigeminal nucleus | nd | nd | ++ | ++ |
| Other nucleus | nd | nd | ++ | ++ |
| Spinal cord | ||||
| Dorsal horn (layers I and II) | nd | nd | ++ | ++ |
| Motoneurons (ventral horn) | nd | nd | ++ | +++ |
Relative immunoreactivity was evaluated on brain and spinal cord tissue sections, processed for immunohistochemistry as described in Materials and Methods. The relative immunoreactivity for PDGF-αR was subjectively rated as follows: −, absent; +, low; ++, moderate; +++, high; nd, not determined.