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Homomeric GluR2(i) channels have a very low conductance. A, Whole-cell response activated by 300 μm glutamate in the presence of 30 μm CZD from a cell expressing GluR2(i) (arrow indicates application). B, A current-variance plot (fitted with a linear regression) for a whole-cell response from a cell expressing GluR2(i). The slope gave a mean conductance of 313 fS for this cell. The holding potential was −80 mV.
