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Diagram depicting hypothesized basal ganglia circuitry in (A) normal basal ganglia. B, Parkinsonian basal ganglia with GDNF. GPe, Globus pallidus externus; STN, subthalamic nucleus;GPi, globus pallidus internus (enteropeduncular nucleus); SNc, substantia nigra pars compacta;SNr, substantia nigra pars reticulata;VA-VL, ventroanterior and ventrolateral nuclei of the thalamus; D1, D2, D1 and D2 receptors of the striatum.
