Table 1.
Control side | Lesion side | % (L/C) | |
Striatal dopamine content (pmol/μg) | 5.77 | 1.07 | 18.54 |
Control side | Lesion side | % (L/C) | |
Number of TH-IR neurons | 5818 | 7490 | 128.74 |
Before capsule implantation | After MFG axotomy | Δ Turns/min | |
Amphetamine-induced rotations (turns/min) | −0.33 | −6.21 | −5.88 |
Values for striatal DA content, number of TH+neurons, and number of turns/min for the animal shown in Figure6D–F. Note the apparent increase in the number of TH-IR on the lesioned side, as compared with the nonlesioned side. Also note the strong contralateral (negative) turning experienced by the animal after axotomy. Turning contralateral to the lesion was also seen in four additional animals that had received a capsule containing GDNF-secreting BHK cells.