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. 1997 Jan 1;17(1):204–215. doi: 10.1523/JNEUROSCI.17-01-00204.1997

Fig. 3.

Fig. 3.

Activation of AMPARs in basal ganglia neurons by different agonists. A, Traces of currents activated by 100 msec pulses of 1 mm glutamate, AMPA, and kainate in outside-out patches isolated from nigral dopaminergic neurons. Glutamate- and kainate-activated current are from the same patch, and AMPA-activated current is from a different patch.B, Bar graph of the average amplitude of the nondesensitizing current component relative to that of the respective peak current activated by 1 mm glutamate, AMPA, and kainate for the populations of basal ganglia neurons investigated. The amplitude of the nondesensitizing current was measured at the end of the 100 msec agonist pulse. C, Cross-desensitization of kainate-activated currents by AMPA in a nucleated patch isolated from a subthalamic nucleus neuron. Top and bottom traces, Current activated by 500 μm AMPA.Middle trace, Application of 1 mm kainate in the maintained presence of 500 μm AMPA did not evoke detectable currents; recording was obtained between topand bottom traces from the same nucleated patch. Membrane potential, −60 mV; Na+-rich external solution (50 μmd-AP5) in all experiments.