Fig. 4.
AMPARs expressed in different types of basal ganglia neurons differ in deactivation and desensitization kinetics.A, Traces of current activated by 1 msec glutamate pulses in outside-out patches. Top trace, Striatal principal neuron patch; bottom trace, globus pallidus neuron patch. B, Bar graph of average deactivation time constants of AMPAR-mediated currents in the types of basal ganglia neurons investigated. C, Traces of current activated by 100 msec glutamate pulses in outside-out patches. Top trace, Striatal principal neuron patch; bottom trace, striatal cholinergic interneuron patch.D, Bar graph of average desensitization time constants of AMPAR-mediated currents in the types of basal ganglia neurons investigated. All data are from outside-out patches. Membrane potential, −60 mV; glutamate concentration, 1 mm; Na+-rich external solution (50 μmd-AP5) in all experiments.
