Fig. 1.

Effects of the integrin blocking peptide GAVSTA on LTP. a–c, Field EPSPs evoked by single stimulation pulses delivered to the Schaffer commissural projections were recorded in CA1 dendrites of hippocampal slices. Responses recorded at 2 (a) and 40 min (b,c) after TBS are shown superimposed with baseline EPSPs recorded before TBS in slices preincubated with 1 mm GAVSTA (a, b) or 2 mm control peptide ASG (c) for 50–90 min (calibration: 1 mV, 10 msec). d, The time course of potentiation in the presence of 0.8 mm GAVSTA (n = 16) or control peptide (2 mm ASG or 0.8 mm GRADSP;n = 16 total) is shown with the results expressed as the percent change (group mean ± SEM) from the average baseline field EPSP slope, measured during 15 min of recording before TBS (arrow). Open circles represent responses in GAVSTA-treated slices (n = 10) before administration of TBS.