Fig. 4.

GAVSTA does not affect the NMDA receptor-mediated EPSP component. Responses elicited by single stimulation pulses delivered to the Schaffer commissural projections were recorded in the presence of 20 μm CNQX and low Mg²⁺ (50–100 μm). The plotted data are group means (± SEM) represented as the percent change from the average baseline slope measured 15 min before the start of constant infusion of 1 mm GAVSTA (n = 7). Subsequent infusion of the NMDA receptor antagonist AP5 (200 μm) was initiated where indicated. Typical responses recorded at the times indicated above the graph are shown.