Fig. 7.

Effect of RGDS peptides on previously established LTP. Field EPSPs were recorded in CA1, and LTP was induced at time 0 with TBS (arrow). RGDS (1 mm RGDS or 0.2 mm GRGDSP; n = 13 total) or control (vehicle or 6 mm tetraglycine; n = 17 total) peptides were infused into the interface chamber 10 min after TBS was administered to a slice (bar). Group means (± SEM) of the change in baseline EPSP initial slope (circles) are shown. Two-tailed t test between the two groups of slices at 70 min after induction:p < 0.01.