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. 1997 Feb 15;17(4):1271–1281. doi: 10.1523/JNEUROSCI.17-04-01271.1997

Fig. 6.

Fig. 6.

MT-III-deficient mice exhibit an enhanced increase in GFAP expression associated with aging. GFAP mRNA and MT-I mRNA in brains of wild-type mice (+/+) and MT-III-deficient mice (−/−) were quantitated by solution hybridization. Values are mean ± SEM. GFAP mRNA levels were significantly higher in 24-month-old mutant mice (n = 11), as compared with 24-month-old wild-type mice (n = 7).p < 0.05, unpaired t test. GFAP mRNA levels were also significantly higher in 24-month-old mice of both genotypes, as compared with 6-month-old wild-type mice (n = 4) and 6-month-old mutant mice (n = 5). p < 0.05. No significant differences in MT-I mRNA levels were detected among any group.