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. 1997 Feb 15;17(4):1271–1281. doi: 10.1523/JNEUROSCI.17-04-01271.1997

Fig. 7.

Fig. 7.

MT-III selectively protects CA3 neurons from seizure-induced death. A, Average semiquantitative neuron injury scores (mean ± SEM) in the CA3 hippocampal field of MT-III transgenic mice (TG, n = 38), wild-type mice (+/+, n = 114), and MT-III-deficient mice (−/−, n = 45) 3 d after kainate treatment. *p < 0.02, as compared with wild-type mice; p < 0.01, as compared with MT-III transgenic mice, unpaired t test. B, CA3 neuron injury scores are plotted in relation to seizure intensity, as assessed by cumulative convulsion time. Values are mean ± SEM,n ≥ 9 for mutant mice; n ≥ 14 for wild-type mice; n ≥ 7 for MT-III transgenic mice. CA3 neuron damage scores for MT-III-deficient mice were significantly greater than for both wild-type and MT-III transgenic mice after <100 sec of convulsing; p < 0.05 andp < 0.01, respectively, unpaired ttest. CA3 neuron injury scores in MT-III-deficient mice and wild-type mice were greater than in MT-III transgenic mice after moderate seizures characterized by 100–300 sec of convulsions.C, Neuron injury in the CA1 hippocampal field of the same mice was not significantly affected by MT-III level.