Table 1.

Response of wild-type (+/+), MT-III-deficient (−/−), and MT-III transgenic (TG) mice to kainic acid

Genotype	Genetic background	Percent seizing	Latency (min)	Total convulsion time (sec)	Mortality (%)
+/+	hybrid	74	29.3  ± 3.0	121  ± 18	18
−/−	hybrid	86	21.5  ± 4.1	221  ± 251-160	43*
TG	hybrid	71	31.5  ± 3.5	115  ± 20	11
+/+	129 Sv	76	30.6  ± 4.0	107  ± 25	0
−/−	129 Sv	88	20.9  ± 3.0	184  ± 30	13

Hybrid mice were given 25 mg of kainate/kg body weight and congenic mice (129 Sv) were given 35 mg of kainate/kg body weight. Latencies and convulsion times are the means ± SEM, n ≥ 24 for each group.

^*Significantly greater than +/+ hybrid mice;p < 0.05, χ² analysis.

F1-160: Significantly greater than +/+ hybrid mice; p < 0.01, unpaired t test.