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α-MSH given centrally and/or peripherally inhibited increases in circulating TNF-α induced by central injection of LPS. Overall, ANOVA was significant (p < 0.001). Dunnett’s test: **p < 0.01 relative to saline (i.c.v.) + saline (i.p.); +p < 0.05 relative to saline (i.c.v.) + α-MSH (i.p.) p< 0.01 relative to α-MSH (i.c.v.) + saline (i.p.).
