Fig. 4.

Aglycemia induces an inward current and increases the membrane conductance in spiny neurons. A, During a single-microelectrode voltage-clamp experiment, the voltage was monitored (see top part). The glucose deprivation induced an inward current. The black arrows indicate the onset of aglycemia (a), 15 min of aglycemia (b), the onset of the washout after 25 min of aglycemia (c), and 10 min of washout (d). Interruptions of the traces between two open arrowsrepresent different periods of recording: 14 min betweena and b, 7 min between band c, and 8 min between c andd. The downward deflections are induced by negative current steps. B, This part of the figure shows single sweeps recorded at higher speed at the same times as those indicated inA. Current and voltage calibrations in Aapply also for B. The holding potential during the experiment was −85 mV.