Fig. 6.

Aglycemia hyperpolarizes LA striatal interneurons and decreases their membrane input resistance. A, Thetop part represents selected chart records of the membrane potential changes caused by glucose deprivation. Theblack arrows indicate the onset of aglycemia (a), 10 min of aglycemia (b), the onset of the washout (c), and 10 min of washout (d). Interruptions of the traces between two open arrows represent different periods of recording: 8 min betweena and b, 3 min between band c, and 7 min between c andd. The bottom part shows the current trace monitored during the recording. The downward voltage deflections are induced by negative current steps. B, Single sweeps recorded at higher speed at the same times as indicated inA. In Ac and Bc, thedotted line indicates the original resting membrane potential (−59 mV). C, A single action potential followed by a long-lasting hyperpolarization (a) is induced by a depolarizing current pulse (b) in an LA striatal interneuron. The dotted line represents the resting membrane potential of the neuron (−59 mV).