Fig. 1.

The effects of (1A) 23-mer and (1B) 27-mer S-ODNs on OLs with membrane sheets. DIV primary cultures (12–14) were immunostained with the A007 antibody after a 24 or 48 hr exposure to 5.0 μm S-ODNs. Both 23-mer and 27-mer antisense S-ODNs led to a reduction in the percentage of OLs with membrane sheets after a 24 and 48 hr exposure. The data for each time point were based on four different experiments; two to four mouse brains were pooled for each experiment. Each time point is the mean ± SE for the four experiments. At each time point, 3–10 coverslips were counted for each group (Control,Random, Sense, Antisense). All A007⁺ OLs (500–1000 OLs) on every coverslip were counted.