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. 1997 Mar 15;17(6):2056–2070. doi: 10.1523/JNEUROSCI.17-06-02056.1997

Fig. 2.

Fig. 2.

The effects of 23-mer S-ODNs on OLs with membrane sheets. DIV primary cultures (12–14) were incubated with 2.5 μm sense or antisense S-ODNs for 1–7 d (13–21 DIV) and then immunostained with the A007 antibody. Exposure to antisense, but not sense, S-ODNs led to a reduction in the percentage of OLs with membrane sheets from 1–7 d of treatment. Each time point is the mean ± SE for seven different experiments. An average of eight coverslips was counted for each group at each time point, and all of the A007+ OLs (500–1500 OLs) on every coverslip were counted. The difference in the percentage of OLs with membrane sheets treated with PLP antisense as compared with control or sense-treated cultures was significant (p < 0.05, one-tailed t test) at 5 and 7 d.