Table 1.
Sources of brain tissue
| Case | Source | Age | Sex | PMI | MMSE | Cause of death | Medications |
|---|---|---|---|---|---|---|---|
| Ag-AD | |||||||
| 1 | ADRC clinic | 88 | F | 14 | 8 | Cardiac arrest | Dyazide, haloperidol, ibuprofen, multivitamins |
| 2 | ADRC clinic | 85 | M | 12 | 20, 11 | Cardiopulmonary arrest | Loxapine |
| 3 | ADRC clinic | 90 | M | 8 | 13 | Myocardial infarction | Aspirin |
| 4 | ADRC clinic | 73 | F | 2 | 18 | Cardiopulmonary arrest | Furosemide, potassium, digoxin, enalapril, nifedipine |
| Clorazepic acid, trazodone, tylenol, coumadin | |||||||
| 5 | TRCP | 70 | M | 2.5 | 18 | Cardiopulmonary arrest | Nortriptyline |
| 6 | ADRC clinic | 86 | F | 2.25 | 21, 19 | Respiratory failure | Hydrochlorothiazide, furosemide, naproxen, tacrine |
| meclizine, digoxin, diclofenac sodium, amitriptyline | |||||||
| 7 | ADRC clinic | 74 | M | 6.5 | 23 | Cardiac arrest | Bumetanide, colchicine |
| 8 | ADRC clinic | 73 | F | 9.5 | 2 | Respiratory failure | Digoxin, haloperidol, ranitidine, omperazole, estrogen, prednisone, theophylline |
| Controls | |||||||
| 9 | TRCP | 89 | M | 9 | N/A | Cardiac arrest | None |
| 10 | TRCP | 83 | M | 7.5 | N/A | Aspiration pneumonia, cancer | Vicodin, morphine, triazolam |
| 11 | TRCP | 71 | F | 4 | N/A | Chronic pulmonary disease | Theophylline, metaproterenol, iron, prednisone |
| 12 | TRCP | 65 | M | 4.5 | N/A | Cardiac arrest | Captopril, furosemide, nitroglycerine, iron, fluoxetine, diltiazem, coumadin, aspirin, albuterol, ipra-tropium bromide, triamcinolone acetonide |
| 13 | TRCP | 81 | F | 6 | N/A | Cardiac arrest | Digoxin, prednisone, albuterol, trazodone |
| 14 | TRCP | 77 | M | 6.5 | N/A | Cardiac arrest | Thyroid hormone |
| 15 | TRCP | 76 | F | 4.5 | N/A | Myocardial infarction | Prednisone, lorazepam, theophylline |
| nAg-AD | |||||||
| 16 | ADRC clinic | 79 | M | 12 | 23, 20 | Pneumonia | Dihydroergotamine mesylate, aspirin, florinef, salt tablets, piroxicam |
| 17 | ADRC clinic | 73 | M | 8 | 9 | Cardiopulmonary arrest | Carbidopa, amitriptyline, vitamin E, selegeline |
| 18 | ADRC clinic | 72 | F | 12 | 5 | Brain embolism | Phenytoin, estrogen |
| 19 | ADRC clinic | 73 | M | 6 | 19, 6 | Cardiac arrest | Ergometrinine, aspirin, imipramine |
| 20 | ADRC clinic | 77 | M | 6.5 | 19 | Cardiac arrest | Imipramine, cycloserine (study), quinidine |
| 21 | ADRC clinic | 90 | F | 8.5 | 18 | Cardiac arrest | Captopril, aspirin, multivitamins |
| 22 | ADRC clinic | 80 | F | 3 | 19 | Stroke | Nitrofurantoin, carbidopa, oxybutynin, warfarin, Atenolol, triamterine |
| 23 | ADRC clinic | 95 | F | 9.5 | 14 | Cardiopulmonary arrest | None |
Ag-AD, Aggressive Alzheimer’s disease subgroup; nAg-AD, non-aggressive AD subgroup; ADRC, Alzheimer’s Disease Research Center; TRCP, Tissue Repository Consent Program; MMSE, Mini Mental State Exam scores (two scores reflect two evaluations in consecutive years); PMI, postmortem interval (hours).