Fig. 3.

The effect of 50 additional stimulus-free days after the retest trial on the GST (A) and the behavioral seizure response (B).A, The GST is significantly lower compared with the naive state (trial 1) up to 50 d after the retest trial. Data are the mean ± SEM of a subset of animals rechallenged 50 d after the retest trial, which followed a 1, 2, or 3 week stimulation-free interval that was preceded by eight daily seizures (n = 14); a, p< 0.001 versus trial 1; b, p < 0.05 versus trial 8. B, The behavioral seizure response continues to change during an additional 50 d stimulation-free interval. Data are the median seizure score of the animals inA (n = 5, 6, 3; 1, 2, 3 weeks, respectively).