Table 1.
Long-term changes in the generalized seizure threshold and the threshold to the first MJ: effect of the number of seizures and the duration of the stimulus-free interval (SFI)
| Trials +4 wk SFI (no.) | Measured threshold (sec)1-a | Predicted trial (no.)1-b | Trials +8 wk SFI (no.) | Measured threshold (sec) | Predicted trial (no.) | 8 Trials + weeks SFI | Measured threshold (sec) | Predicted trial (no.) |
|---|---|---|---|---|---|---|---|---|
| Generalized seizure threshold | ||||||||
| 1 | 315.8 ± 10.0 | 2.05 | 1 | 230.9 ± 11.9 | 4.62 | |||
| 2 | 328.3 ± 24.5 | 1.82 | 2 | 427.8 ± 17.4 | 0.21 | 2 | 220.8 ± 9.8 | 5.22 |
| 4 | 325.0 ± 20.4 | 1.88 | 4 | 311.8 ± 30.3 | 2.15 | 3 | 266.2 ± 10.7 | 3.27 |
| 6 | 282.3 ± 12.4 | 2.83 | 4 | 207.2 ± 9.7 | 6.64 | |||
| 8 | 207.2 ± 9.7 | 6.64 | ||||||
| Trials +4 wk SFI (no.) | Measured threshold (sec)1-a | Predicted trial (no.)1-b | Trials +8 wk SFI (no.) | Measured threshold (sec) | Predicted trial (no.) | 8 Trials + weeks SFI | Measured threshold (sec) | Predicted trial (no.) |
|---|---|---|---|---|---|---|---|---|
| Threshold to first MJ | ||||||||
| 1 | 261.4 ± 17.6 | 1.58 | 1 | 209.4 ± 13.2 | 3.40 | |||
| 2 | 247.2 ± 17.9 | 1.94 | 2 | 256.8 ± 9.6 | 1.69 | 2 | 193.3 ± 10.8 | 4.54 |
| 4 | 240.8 ± 7.0 | 2.12 | 4 | 228.2 ± 11.6 | 2.55 | 3 | 232.9 ± 11.4 | 2.38 |
| 6 | 246.7 ± 17.4 | 1.95 | 4 | 180.0 ± 9.0 | 5.95 | |||
| 8 | 180.0 ± 9.0 | 5.95 | ||||||
F1-a
Mean ± SEM of the latency (seconds) to the seizure endpoint for the sample.
F1-b
Value is the calculated point on thex-axis for the sample threshold using the regression equation generated from the data depicted in Figure 2. The equation is based on the grand mean of the latency to the sustained generalized seizure (y = − .04x4 + 0.25x3 + 5.72x2 − 4.39x + 443.4) or the first MJ (y = 0.09x4 − .01x3 + 18.54x2 −7.86x + 361.74) for all animals on a per-trial basis and is used to estimate the population.